The Tesori Family Foundation began by supporting several charities to support, with focuses ranging from childhood homelessness to battered women’s shelters, from children battling disease like cancer to animal rescue charities like the Jacksonville Humane Society. Shortly after Paul and Michelle Tesori's son Isaiah was born sporting his extra special chromosome (more commonly referred to in the medical community as Down syndrome), the Tesoris expanded the foundation’s programming adding specific programs like Buddy Baskets and the All-Star Kids Clinic to support the Down syndrome community and other children with special needs.